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KMID : 0882420050690060631
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Korean Journal of Medicine
2005 Volume.69 No. 6 p.631 ~ p.641
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The relationship of adiponectin, Leptin and ghrelin to insulin resistance and cardiovascular risk factors in human obesity
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김종엽/Kim JY
신현원/정인경/조성휘/민성전/이성진/박철영/오기원/홍은경/김형규/김두만/Shin HW/Jeong IK/Cho SW/Min SJ/Lee SJ/Park CY/Oh KW/Hong EG/Kim HK/Kim DM
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Abstract
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Background:Adiponectin, letin and ghrelin are considered to take part in the regulation of energy metabolism. We investigated the relationship between these adipokines and body mass index (BMI), regional adiposity, insulin resistance and cardiovascular risk factors in human.
Methods:Eighty six (Male : Female = 36 : 50, Age = 21-71 year old, BMI : 18 - 39.5 kg/m2) subjects without known medical problems participated in this study. Subjects were grouped based on BMI or visceral fat area (VFA) and gender. We measured lipid concentration, fasting glucose, fasting insulin, insulin resistance (HOMA-IR) and high sensitivity CRP (hsCRP). Body fat distribution was determined by computed tomography. Fasting serum adiponectin, leptin, and ghrelin were measured by ELISA.
Results:The group of BMI over 25 kg/m2 showed significant difference in waist circumference (WC), total fat area (TFA), subcutaneous fat area (SFA), VFA, Triglyceride (TG), hsCRP and leptin. Visceral fat dominant (VFD) group (VFA>or=100 cm2 or VFA/SFA>or=0.4) showed significant difference in age, BMI, WC, TFA, SFA, free fatty acid, HOMA-IR, hsCRP, adiponectin, leptin and ghrelin. Leptin was positively correlated with BMI, waist hip ratio (WHR), TFA, VFA, SFA, low-density lipoprotein cholesterol (LDL-C), HOMA-IR and fasting insulin. Adiponectin was negatively correlated with BMI, WHR, TFA, VFA, HOMA-IR and positively correlated with High-density lipoprotein cholesterol (HDL-C). Ghrelin level was negatively correlated with WHR, VFA, fasting glucose, HOMA-IR and positively correlated with HDL-C. And leptin was negatively correlated with ghrelin. As regional adiposity, SFA was positively correlated with leptin, and VFA was negatively correlated with adiponectin and ghrelin and positively correlated with leptin.
Conclusions:This study demonstrated that VFA had more significant association with lipid metabolism and adipokine secretion than BMI and leptin levels were inversely correlated with ghrelin level.
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KEYWORD
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